ISDIN Retinal Intense Serum is a powerful overnight treatment that combines 0.1% retinaldehyde for cellular renewal, bakuchiol for natural firming, and melatonin for antioxidant protection. The encapsulated retinaldehyde delivers prescription-strength results without irritation while bakuchiol mimics retinol's benefits to improve elasticity. Melatonin works to neutralize free radicals accumulated during daytime exposure. Clinically proven to reduce wrinkles by 49% in 12 weeks, this serum is ideal for those seeking professional anti-aging results with minimal irritation. The formula is particularly effective for addressing fine lines, loss of firmness, and oxidative stress damage while you sleep.